Many factors lead to the frustrating cycle of weight gain and weight loss \u2014 but the driving force may be fat cells keeping a\u00a0memory of obesity<\/u><\/a>.<\/p>\n That\u2019s according to a recent study that was first published in the journal Nature last fall.<\/p>\n Researchers say that fat cells influence abnormal metabolic pathways in the body long after pounds are shed, which could make it more likely for people to regain weight.<\/p>\n STUDY DIRECTLY COMPARES ZEPBOUND AND WEGOVY FOR WEIGHT-LOSS RESULTS<\/u><\/strong><\/a><\/p>\n The team of Swiss scientists were curious whether\u00a0regaining weight<\/u><\/a> after slimming down is due to “metabolic memory,” where the body remembers and strives to return to its former state of obesity.<\/p>\n Many factors lead to the frustrating cycle of weight gain and weight loss \u2014 but the driving force may be fat cells keeping a\u00a0memory of obesity.<\/span> (iStock)<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n They analyzed chemical markers on fat cells in mice who were fed a high-fat diet. Next, when the mice were fed only a standard meal, the researchers analyzed their fatty tissue after they had lost weight, according to the study write-up.<\/p>\n The team then compared these samples to a lean mice group that was fed a standard meal<\/a> to see if the chemical markers on the fat cells were associated with unhealthy changes in the body.<\/p>\n DOCTORS WARN OF ‘TRIFECTA’ OF CHRONIC ILLNESSES PLAGUING AMERICANS AFTER MAHA REPORT<\/u><\/strong><\/a><\/p>\n The mice on the high-fat diet continued to have unhealthy changes in their metabolism after losing weight, including more difficulty in regulating sugar metabolism, more inflammation and abnormal fat storage.<\/p>\n Mice who were previously obese gained weight faster compared to the control group after they ate a high-fat diet \u2014 suggesting a continued impairment in metabolism after losing weight<\/a>, the researchers found.<\/p>\n Mice who were previously obese gained weight faster compared to the control group after they ate a high-fat diet \u2014 suggesting a continued impairment in metabolism after losing weight.<\/span> (iStock)<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n The study also looked at human samples, analyzing how the genes in fat cells can lead to unhealthy changes in the body as they did in mice.\u00a0<\/p>\n The researchers analyzed the fatty tissues of participants before and after they underwent bariatric surgery, comparing them to the fatty cells of lean individuals who did not have a history of obesity.<\/p>\n “This recent research suggests that after someone loses weight, their fat cells don\u2019t fully go back to \u2018normal.\u2019”<\/p>\n <\/p><\/blockquote>\n In obese individuals, the genes from fat cells continued to function abnormally in the body, leading to more inflammation and metabolic problems two years after losing weight.<\/p>\n One limitation of the study\u00a0is that it only looked at one type of cell \u2013 fat cells. More\u00a0research is needed to determine\u00a0whether other cells or tissues in the body also keep a memory of being overweight, the researchers acknowledged.<\/p>\n Fat cells indeed have a memory of being obese, which can make it easier to regain weight and stay in a state that promotes inflammation and metabolic issues, confirmed\u00a0Gretchen Zimmermann, registered dietitian and vice president of clinical strategy at\u00a0Vida Health, a virtual obesity care provider. (She was not part of the study.)<\/p>\n “This recent research suggests that after someone loses weight, their fat cells don\u2019t fully go back to ‘normal,\u2019” Zimmermann told Fox News Digital.\u00a0<\/i><\/p>\n The researchers analyzed the fatty tissues of participants before and after they underwent bariatric surgery, comparing them to the fatty cells of lean individuals who did not have a history of obesity.<\/span> (iStock)<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n But while biology plays a critical role in obesity, it\u2019s not everything, she cautioned.<\/p>\n “<\/i>A complex mix of genetics, biology, environment, psychology, medications and social determinants all shape obesity,” Zimmermann said.<\/p>\n “Keep moving, eating real food and building muscle.”<\/p>\n <\/p><\/blockquote>\n Healthy habits can counteract the genetics that promote weight gain.<\/p>\n Ideally, the expert said, this entails getting a combination of physical activity<\/a> (including strength training), a sufficient amount of protein and fiber, and phytonutrients from plants that counter oxidative stress and chronic inflammation, according to Zimmermann.\u00a0<\/p>\n CLICK HERE TO GET THE FOX NEWS APP<\/u><\/strong><\/a><\/p>\n “Keep moving, eating real food and building muscle,” she said.<\/p>\n “These behaviors reduce inflammation, improve blood sugar control, contribute to a healthy microbiome and protect metabolism \u2014 even if weight doesn\u2019t drop much or stays the same.”<\/p>\n Healthy habits can counteract the genetics that promote weight gain, researchers say.<\/span> (iStock)<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n For some, however, the underlying issue may lie in epigenetics<\/u><\/a>, which involves how a person\u2019s behaviors and surrounding environment influence how genes work in the body, according to the Centers for Disease Control and Prevention.<\/p>\n CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER<\/u><\/strong><\/a><\/p>\n “Obesity is a chronic relapsing condition that has an epigenetic cause,”\u00a0Dr. Caroline Apovian, professor of medicine at Harvard Medical School and co-director of the Center for Weight Management and Wellness at Brigham and Women’s Hospital, told Fox News Digital.<\/p>\n For more Health articles, visit\u00a0<\/u><\/strong><\/i><\/a>www.foxnews.com\/health<\/u><\/strong><\/i><\/a><\/p>\n People who are more prone to storing calories may have a harder time losing weight and keeping it off through diet and exercise<\/a>, compared to those who may have an easier time, according to Apovian, who was not involved in the study.<\/p>\n Fox News Digital reached out to the study authors for comment.\u00a0<\/p>\n <\/div>\nStudy findings<\/strong><\/h2>\n
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\u2018Complex mix\u2019 of factors<\/strong><\/h2>\n
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